Immunogenicity and reactogenicity of the Biken acellular pertussis vaccine in young adults.
Vaccine
; 19(4-5): 403-8, 2000 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-11027800
ABSTRACT
To assess the reactogenicity and immunogenicity of the Biken acellular pertussis vaccine (Pa) following administration of a single vaccine dose to young adults with or without a history of prior pertussis immunization, 104 healthy, male and female adults without primary pertussis immunization were enrolled in Mainz (former West Germany; "not previously pertussis vaccinated", N-PPV-group); in parallel, 103 adults with a history of having received >/=four doses of a combined diphtheria-, tetanus-toxoid, whole-cell pertussis vaccine (DTwP) were enrolled in Magdeburg (former East Germany; "previously pertussis-vaccinated", PPV-group). Large areas of redness (>20 mm) were seen in 2.9%/1.0% of subjects in the N-PPV/PPV group, and a large swelling was seen in 6.8%/1.0%, respectively. As compared to baseline concentrations, antibody titers to PT and FHA were 77-(PT)/64-(FHA) (N-PPV group) and 94-(PT)/126-(FHA) fold (PPV group) higher. The study vaccine was safe and induced infrequent and mostly mild, local and general symptoms that all resolved spontaneously; it was highly immunogenic in adults, whether or not they had been previously vaccinated with DTwP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Virulencia de Bordetella
/
Vacuna contra la Tos Ferina
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Vaccine
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania