The "aspirin" of the new millennium: cyclooxygenase-2 inhibitors.
Mayo Clin Proc
; 75(10): 1027-38, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11040851
ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis via the cyclooxygenase (COX) enzyme, the key to both therapeutic benefits and toxicity. COX enzyme exists in 2 isoforms, COX-1 and COX-2. COX-1 enzyme is thought to mediate "housekeeping" or homeostatic functions, and COX-2 is considered an inducible enzyme in response to injury or inflammation. COX-2 inhibitors are the "next-generation" NSAIDs that may selectively block the COX-2 isoenzyme without affecting COX-1 function. This may result in control of pain and inflammation with a lower rate of adverse effects compared with older nonselective NSAIDs. Rapidly evolving evidence suggests that COX-2 enzyme has a diverse physiologic and pathologic role. This article addresses the role of COX-2 enzyme in health and disease as well as the potential therapeutic value and safety issues related to COX-2 inhibition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peroxidasas
/
Antiinflamatorios no Esteroideos
/
Inhibidores de la Ciclooxigenasa
/
Isoenzimas
Límite:
Humans
Idioma:
En
Revista:
Mayo Clin Proc
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos