Effect of hyperoxia on vascular endothelial growth factor levels in a wound model.
Arch Surg
; 135(11): 1293-7, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11074883
ABSTRACT
HYPOTHESIS:
Hyperbaric oxygen (HBO) therapy increases vascular endothelial growth factor (VEGF) levels in wounds.DESIGN:
Wounds were monitored for oxygen delivery during HBO treatment, and wound fluids were analyzed for VEGF and lactate on days 2, 5, and 10 following wounding.SETTING:
Experimental animal model.INTERVENTIONS:
Rats were randomized to HBO therapy and control groups. The HBO therapy was administered for 90 minutes, twice daily with 100% oxygen at 2.1 atmospheres absolute. Treatment was administered for 7 days following wounding. MAIN OUTCOMEMEASURES:
Vascular endothelial growth factor, PO(2), and lactate levels in wound fluid were measured on days 2, 5, and 10.RESULTS:
Wound oxygen rises with HBO from nearly 0 mm Hg to as high as 600 mm Hg. The peak level occurs at the end of the 90-minute treatment, and hyperoxia of lessening degree persists for approximately 1 hour. The VEGF levels significantly increase with HBO by approximately 40% 5 days following wounding and decrease to control levels 3 days after exposures are stopped. Wound lactate levels remain unchanged with HBO treatment (range, 2.0-10.5 mmol/L).CONCLUSIONS:
Increased VEGF production seems to explain in part the angiogenic action of HBO. This supports other data that hypoxia is not necessarily a requirement for wound VEGF production.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Factores de Crecimiento Endotelial
/
Linfocinas
/
Oxigenoterapia Hiperbárica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Surg
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos