[Aplasia after azathioprine administration: role of the thiopurine methyltransferase genetic polymorphism]. / Aplasia medular tras administración de azatioprina: papel de polimorfismo genético de la tiopurina metiltransferasa.
Med Clin (Barc)
; 115(8): 299-301, 2000 Sep 16.
Article
en Es
| MEDLINE
| ID: mdl-11093885
ABSTRACT
BACKGROUND:
Azathioprine is an immunosuppressor drug widely used in the treatment of autoimmune diseases. Adverse effects during treatment are related to the activity of thiopurine methyltransferase (TPMT), an enzyme which plays a role in azathioprine metabolism. The presence of the allelic variants of the TPMT gene allows us to classify patients into three different groups high, moderate and low risk of myelosuppression after receiving standard doses of azathioprine. PATIENTS ANDMETHODS:
Study of the allelic variants of the TPMT gene in the positions 460 and 719 with PCR methods in a patient with Crohn's disease, who developed aplasia after receiving azathioprine. The study was extended to his relatives.RESULTS:
The patient under study carried the most frequent variant allele of the TPMT gene associated with low enzymatic activity. The mother and one sister of the patient were also carriers of this allelic variant.CONCLUSIONS:
Genotyping the allelic variants of the TPMT gene is a useful method to identify patients at moderate or high risk of myelosuppression after administration of azathioprine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Azatioprina
/
Aplasia Pura de Células Rojas
/
Inmunosupresores
/
Metiltransferasas
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
Es
Revista:
Med Clin (Barc)
Año:
2000
Tipo del documento:
Article