I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo.
Blood
; 96(13): 4039-45, 2000 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-11110671
ABSTRACT
Several chemokines have been shown to act as angiogenic molecules or to modulate the activity of growth factors such as fibroblast growth factor 2 (FGF-2) and vascular endothelial growth factor (VEGF). The detection of the CC chemokine receptor (CCR) 8 message in human umbilical vein endothelial cells (HUVECs) by reverse transcription- polymerase chain reaction (RT-PCR) and RNase protection assay (RPA), prompted us to investigate the potential role exerted by the CC chemokine I-309, a known ligand of such receptor, in both in vitro and in vivo angiogenesis assays. We show here that I-309 binds to endothelial cells, stimulates chemotaxis and invasion of these cells, and enhances HUVEC differentiation into capillary-like structures in an in vitro Matrigel assay. Furthermore, I-309 is an inducer of angiogenesis in vivo in both the rabbit cornea and the chick chorioallantoic membrane assay (CAM).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Neovascularización Fisiológica
/
Quimiocinas CC
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Blood
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia