Up-regulation of serine/threonine protein phosphatase type 2A regulatory subunits during methylprednisolone-induced differentiation of leukaemic HL-60 cells.
Clin Lab Haematol
; 22(5): 271-4, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11122267
ABSTRACT
Serine/threonine protein phosphatase 2A (PP2A) may play a role in leukaemic cell differentiation of the HL-60 myeloid leukaemic cell-line after methylprednisolone induction. We have investigated the specific enzyme activity and expression of catalytic and regulatory subunits of PP2A. The resulting specific enzyme activity and immunoblots showed an increase in enzyme activity and the expression of regulatory subunits after methylprednisolone treatment. There was no change in the expression of PP2A catalytic subunits. It is suggested that the effect of methylprednisolone on leukaemic differentiation may be the result of PP2A upregulation.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metilprednisolona
/
Diferenciación Celular
/
Fosfoproteínas Fosfatasas
/
Antiinflamatorios
Límite:
Humans
Idioma:
En
Revista:
Clin Lab Haematol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Turquía