Effects of FKBP-12 ligands following tibial nerve injury in rats.
J Reconstr Microsurg
; 16(8): 613-20, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11127284
ABSTRACT
The neuroregenerative properties of FK506, an FKBP-12 ligand that inhibits calcineurin, and V-10,367, an FKBP-12 ligand that does not inhibit calcineurin, were evaluated in crush and transection models. Rats were randomly assigned to one of seven groups, including untreated controls and FK506- or V-10,367-treated experimental groups. Following crush or transection nerve injury, animals were assessed with walking tracks, and histomorphometry. FK506-treated animals demonstrated significant functional recovery 11 days following crush and 18 days following transection injury. In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection injury. No statistically significant differences in histomorphometric parameters were identified between any of the groups. The study confirms that FK506 accelerates recovery from tibial nerve injury.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Nervio Tibial
/
Tacrolimus
/
Fármacos Neuroprotectores
/
Proteína 1A de Unión a Tacrolimus
/
Regeneración Nerviosa
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
J Reconstr Microsurg
Asunto de la revista:
NEUROCIRURGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos