The effect of electromagnetic field exposure on the formation of DNA lesions.
Redox Rep
; 5(5): 299-301, 2000.
Article
en En
| MEDLINE
| ID: mdl-11145105
ABSTRACT
In an attempt to determine whether electromagnetic field (EMF) exposure might lead to DNA damage, we exposed SnCl2-treated pBR322 plasmids to EMF and analysed the resulting conformational changes using agarose gel electrophoresis. An EMF-dependent potentiation of DNA scission (i.e. the appearance of relaxed plasmids) was observed. In confirmation of this, plasmids pre-exposed to EMF also were less capable of transforming Escherichia coli. The results indicate that EMF, in the presence of a transition metal, is capable of causing DNA damage. These observations support the idea that EMF, probably through secondary generation of reactive oxygen species, can be clastogenic and provide a possible explanation for the observed correlation between EMF exposure and the frequency of certain types of cancers in humans.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Campos Electromagnéticos
Idioma:
En
Revista:
Redox Rep
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
2000
Tipo del documento:
Article
País de afiliación:
Brasil