Upregulation of glial clusterin in brains of patients with AIDs.
Brain Res
; 888(2): 297-301, 2001 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-11150487
ABSTRACT
Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation markers were absent. In contrast, the relative area and number of GFAP-positive astrocytes and their percent of all white matter glia, increased in some cases but the mean increases were not significant. Clusterin is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not dependent on increases in GFAP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas
/
Neuroglía
/
Complejo SIDA Demencia
/
Síndrome de Inmunodeficiencia Adquirida
/
Chaperonas Moleculares
/
Lóbulo Frontal
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Brain Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos