von Willebrand factor antigen as a prognostic marker in posttraumatic acute lung injury.
Haemostasis
; 30(4): 189-95, 2000.
Article
en En
| MEDLINE
| ID: mdl-11155037
ABSTRACT
The specific endothelial cell product von Willebrand factor antigen (vWfAg) was measured in plasma and lung function tests were carried out and the following lung injury parameters measured P(a)O2/F(i)O2 ratio, static respiratory compliance and Murray's lung injury score (LIS) in a follow-up study of 36 severely traumatized patients. Injury severity score (ISS) and APACHE II scores were calculated. Patients were classified according to the presence or absence of acute respiratory distress syndrome (ARDS) complications and survival versus death. Data collection was performed on admission to hospital and after 1-3, 5, 7, 10 days of ICU stay. On all of the occasions investigated, plasma vWfAg levels in ARDS patients and nonsurvivors were significantly greater than those in patients without ARDS and survivors, respectively. Significant correlations were observed between initial vWfAg concentration and ISS, APACHE II, LIS. Our study suggests that increased concentrations of vWfAg in plasma are predictive of the development of ARDS and signal poor prognosis in patients following severe trauma.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Dificultad Respiratoria
/
Antígenos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Haemostasis
Año:
2000
Tipo del documento:
Article
País de afiliación:
Polonia