Comparative toxicities and pharmacokinetics of intrathecal lipid (amphotericin B colloidal dispersion) and conventional deoxycholate formulations of amphotericin B in rabbits.
Antimicrob Agents Chemother
; 45(2): 612-5, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11158765
ABSTRACT
The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits than did ABCD. Clinically and histologically, ABCD was about threefold less toxic than AMB after a single dose and 3- to 30-fold less toxic after multiple dosing. These data are encouraging for the potential use of ABCD as an intrathecal treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anfotericina B
/
Antifúngicos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos