A novel VIP responsive gene. Activity dependent neuroprotective protein.
Ann N Y Acad Sci
; 921: 115-8, 2000.
Article
en En
| MEDLINE
| ID: mdl-11193814
ABSTRACT
Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolar-acting NAP and through putative interaction with other macromolecules.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido Intestinal Vasoactivo
/
Proteínas de Homeodominio
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2000
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA