ASE-1: an autoantigen in systemic lupus erythematosus.
Lupus
; 9(9): 681-7, 2000.
Article
en En
| MEDLINE
| ID: mdl-11199923
ABSTRACT
ASE-1 is a 55 kDa nucleolar autoantigen. We show that autoantibodies to this antigen occur at a higher frequency in the sera of patients with SLE than in other systemic rheumatic diseases and that the specificity of ASE-1 as a serum marker of SLE increases as the number of epitopes recognized by the sera increases. Autoantibodies to ASE-1 were temporally associated with autoantibodies to HsEg5 but were not found in conjunction with other known serum markers of SLE. The frequency of antibodies to ASE-1 epitopes in a SLE cohort was approximately the same as anti-dsDNA. However, anti-dsDNA is associated with renal involvement, whereas ASE-1 reactivity shows an association with a history of serositis. We conclude that ASE-1 is correlated with serositis and that ASE-1 should be added to a list of autoantigens that are considered important serological features of SLE.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Autoantígenos
/
Proteínas Portadoras
/
Péptidos y Proteínas de Señalización Intracelular
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Lupus
Asunto de la revista:
REUMATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Canadá