Synthesis of N-4909 analogs. Part I. A stimulant of apolipoprotein E secretion in human hepatoma G2 cells.
J Antibiot (Tokyo)
; 53(12): 1385-96, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11217804
ABSTRACT
Analogs of N-4909 (1), which had a stimulating activity for apolipoprotein E (apo E) secretion in Human hepatoma Hep G2 cells, were prepared and their activities examined. Cyclic analogs which had different kinds of amino acids or different number of amino acids from N-4909 (1) showed less effect on apo E secretion from Hep G2 cells. The length of acyl chain was found to be an important factor for the activity. Shorter chain reduced the activity. Linear analogs were also prepared. One of their analogs, N-5849 (17), which had six amino acids was found to have strong activity.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apolipoproteínas E
/
Péptidos Cíclicos
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
/
Hipolipemiantes
Límite:
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón