Local chemotherapy with interferon-alpha for conjunctival mucosa-associated lymphoid tissue lymphoma: a preliminary report.
Ophthalmology
; 108(3): 559-62, 2001 Mar.
Article
en En
| MEDLINE
| ID: mdl-11237911
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of subconjunctival interferon-alpha for the treatment of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma.DESIGN:
Small, noncomparative, interventional case series.PARTICIPANTS:
Five patients with histologically proven conjunctival MALT lymphoma were studied prospectively.METHODS:
Patients were given 1,500,000 international units (IU) of interferon-alpha (IFN-alpha) (Roferon-A) subconjunctivally inside the lesion, three times a week for four weeks. If there was even a minimal response, a further cycle of 1,000,000 IU three times a week for four weeks was administered. Patients received a maintenance dose of 1 million IU, every 15 days for 4 times, after clinical resolution of the lesion. MAIN OUTCOMEMEASURES:
Patients were followed clinically, with slit lamp examination, for evidence of tumor disappearance or recurrence.RESULTS:
Complete response was obtained in all patients. The lesion resolved completely by the eighth week. Four patients did not show any local recurrence with a median follow-up of 21 months (12-36 months). One patient presented with a recurrence after 11 months, in association with systemic lymphoma progression.CONCLUSIONS:
Local chemotherapy with IFN-alpha seems to be an effective treatment modality, alternative to radiotherapy, for conjunctival MALT lymphomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interferón-alfa
/
Linfoma de Células B de la Zona Marginal
/
Neoplasias de la Conjuntiva
/
Antineoplásicos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ophthalmology
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia