Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat.
Neurosci Lett
; 301(1): 5-8, 2001 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-11239703
ABSTRACT
Hyperphosphorylated tau is a pathological hallmark of Alzheimer's disease, but the mechanisms that lead to its formation are poorly understood. To investigate what effect deafferentation of the hippocampus has on the phosphorylation state of tau, we lesioned the entorhinal cortex in rats and looked for hyperphosphorylated tau in the hippocampus at various days post lesioning. After 7 and 21 days, small AT8-positive 'granules' appeared in the molecular layer of the dentate gyrus on the lesioned side. No such staining was seen in the animals injected with saline. This study shows that deafferentation leads to induction of hyperphosphorylated tau. The AT8 positive 'granules' seen resemble the argyrophilic grains that characterize Argyrophilic Grain disease suggesting that lesioning the perforant pathway may serve as a useful model for inducing argyrophilic grains in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas tau
/
Corteza Entorrinal
/
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Reino Unido