The suppository form of antibiotic administration: pharmacokinetics and clinical application.
J Antimicrob Chemother
; 43(2): 177-85, 1999 Feb.
Article
en En
| MEDLINE
| ID: mdl-11252322
ABSTRACT
The rectal route of antibiotic administration might be used effectively when other routes of administration are inadequate or unsuitable. With the use of various adjuvants, the rectal route can provide satisfactory pharmacokinetics and acceptable local tolerance. Experiments in animals have demonstrated the influence of the pharmaceutical formulation of suppositories on the rectal absorption and systemic distribution of beta-lactams and aminoglycosides. In healthy volunteers and in children under treatment, similar adjuvants--mainly glyceride mixtures or non-ionic surface agents--have increased the rectal absorption of aminopenicillins, cephalosporins and macrolides. Other antibiotics, including metronidazole and cotrimoxazole, have been investigated in respect of their potential rectal administration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Supositorios
/
Antibacterianos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia