Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorg Med Chem Lett
; 11(6): 761-4, 2001 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-11277514
ABSTRACT
Malaria continues to represent a very serious health problem in the tropics. The current methods of clinical treatment are showing deficiencies due to the increased incidence of resistance in the parasite. In the present paper we report the design, synthesis, and evaluation of potential antimalarial agents against a novel target, protein farnesyltransferase. We show that the most potent compounds are active against Plasmodium falciparum in vitro at submicromolar concentrations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Transferasas Alquil y Aril
/
Inhibidores Enzimáticos
/
Imidazoles
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos