Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungs.
J Exp Med
; 193(8): 981-6, 2001 Apr 16.
Article
en En
| MEDLINE
| ID: mdl-11304559
ABSTRACT
Although CD4(+) T cells have been shown to mediate protective cellular immunity against respiratory virus infections, the underlying mechanisms are poorly understood. For example, although phenotypically distinct populations of memory CD4(+) T cells have been identified in different secondary lymphoid tissues, it is not known which subpopulations mediate protective cellular immunity. In this report, we demonstrate that virus-specific CD4(+) T cells persist in the lung tissues and airways for several months after Sendai virus infection of C57BL/6 mice. A large proportion of these cells possess a highly activated phenotype (CD44(hi), CD62L(lo), CD43(hi), and CD25(hi)) and express immediate effector function as indicated by the production of interferon gamma after a 5-h restimulation in vitro. Furthermore, intratracheal adoptive transfer of lung memory cells into beta2m-deficient mice demonstrated that lung-resident virus-specific CD4(+) T cells mediated a substantial degree of protection against secondary virus infection. Taken together, these data demonstrate that activated memory CD4(+) T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Respirovirus
/
Linfocitos T CD4-Positivos
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Infecciones por Orthomyxoviridae
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Memoria Inmunológica
/
Pulmón
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos