Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.
J Neuroimmunol
; 116(1): 40-8, 2001 May 01.
Article
en En
| MEDLINE
| ID: mdl-11311328
ABSTRACT
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, plays a critical role in adipocyte differentiation and glucose homeostasis. It has been implicated that PPAR-gamma functions as a regulator of cellular proliferation and inflammatory responses. In the present study, we examined whether troglitazone, a selective PPAR-gamma agonists, ameliorated experimental autoimmune encephalomyelitis (EAE) induced by administration of myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 in C57BL/6 mice. We found that troglitazone attenuated the inflammation and decreased the clinical symptoms. It was suggested that the amelioration was attributed to the attenuation of pro-inflammatory cytokine gene expressions.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiazoles
/
Factores de Transcripción
/
Cromanos
/
Receptores Citoplasmáticos y Nucleares
/
Tiazolidinedionas
/
Encefalomielitis Autoinmune Experimental
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón