Lamellipodia in invasion.
Semin Cancer Biol
; 11(2): 119-28, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11322831
ABSTRACT
In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Seudópodos
/
Endotelio Vascular
/
Movimiento Celular
/
Proteínas del Citoesqueleto
/
Receptores ErbB
/
Invasividad Neoplásica
Límite:
Animals
Idioma:
En
Revista:
Semin Cancer Biol
Asunto de la revista:
NEOPLASIAS
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos