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Mitochondrial DNA depletion, near-fatal metabolic acidosis, and liver failure in an HIV-infected child treated with combination antiretroviral therapy.
Church, J A; Mitchell, W G; Gonzalez-Gomez, I; Christensen, J; Vu, T H; Dimauro, S; Boles, R G.
Afiliación
  • Church JA; Departments of Pediatrics and Laboratory Medicine, Childrens Hospital Los Angeles, and the University of Southern California School of Medicine, Los Angeles, USA.
J Pediatr ; 138(5): 748-51, 2001 May.
Article en En | MEDLINE | ID: mdl-11343055
A child with controlled human immunodeficiency virus infection presented with neurologic deterioration, lactic acidosis, and organic aciduria. Muscle biopsy revealed abnormal mitochondrial (mt) morphology, reduced mt enzyme activities, and mtDNA depletion. After adjustment of antiretroviral therapy to a regimen free of nucleoside analogs, marked improvement was seen in clinical status and mt abnormalities.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acidosis / ADN Mitocondrial / Fallo Hepático / Músculo Esquelético / Terapia Antirretroviral Altamente Activa Límite: Child, preschool / Humans / Male Idioma: En Revista: J Pediatr Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acidosis / ADN Mitocondrial / Fallo Hepático / Músculo Esquelético / Terapia Antirretroviral Altamente Activa Límite: Child, preschool / Humans / Male Idioma: En Revista: J Pediatr Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos