Mitochondrial DNA depletion, near-fatal metabolic acidosis, and liver failure in an HIV-infected child treated with combination antiretroviral therapy.
J Pediatr
; 138(5): 748-51, 2001 May.
Article
en En
| MEDLINE
| ID: mdl-11343055
A child with controlled human immunodeficiency virus infection presented with neurologic deterioration, lactic acidosis, and organic aciduria. Muscle biopsy revealed abnormal mitochondrial (mt) morphology, reduced mt enzyme activities, and mtDNA depletion. After adjustment of antiretroviral therapy to a regimen free of nucleoside analogs, marked improvement was seen in clinical status and mt abnormalities.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acidosis
/
ADN Mitocondrial
/
Fallo Hepático
/
Músculo Esquelético
/
Terapia Antirretroviral Altamente Activa
Límite:
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos