Role of Jak kinases and STATs in cytokine signal transduction.
Int J Hematol
; 73(3): 271-7, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11345192
ABSTRACT
The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after activation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteínas Tirosina Quinasas
/
Transducción de Señal
/
Citocinas
/
Proteínas Proto-Oncogénicas
/
Proteínas de la Leche
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Hematol
Asunto de la revista:
HEMATOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos