Effects of 5-fluorouracil on cell cycle arrest and toxicity induced by X-irradiation in normal mammalian cells.
Cell Prolif
; 34(2): 85-98, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11348424
ABSTRACT
UNLABELLED From clinical studies in cancer patients and experimental in vitro studies, there is evidence of an increased cytotoxic effect, and even synergy, when irradiation is combined with 5-fluorouracil (5-FU). The mechanism for this is unclear. MATERIALS AND METHODS:
Mouse fetuses (C3H) have been exposed in vivo to X-irradiation and 5-fluorouracil (5-FU) as single agents or in combination. Cell proliferation, cell cycle progression, fetal survival and incidence of fetal malformations have been studied.PURPOSE:
The aim of this study was to determine possible synergistic cytotoxic effects when 5-FU and ionizing radiation were combined, particularly concerning the regulation of cell cycle progression in proliferating, non malignant mammalian cells in vivo.RESULTS:
The combination of low-toxic doses of X-irradiation and 5-FU had a synergistic toxic effect in nonmalignant mouse fetuses in vivo. The cell cycle regulation was perturbed and the radiation-induced G2-arrest was eradicated by 5-FU during the initial hours.CONCLUSIONS:
The time for repair of radiation induced DNA-damage is probably reduced, which may explain the increased toxicity of this combination.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rayos X
/
Exposición Materna
/
Embrión de Mamíferos
/
Fluorouracilo
Límite:
Animals
Idioma:
En
Revista:
Cell Prolif
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suecia