CCK mRNA expression in neuroendocrine CRH neurons is increased in rats subjected to an immune challenge.
Brain Res
; 901(1-2): 277-80, 2001 May 18.
Article
en En
| MEDLINE
| ID: mdl-11368978
ABSTRACT
The expression of cholecystokinin (CCK) mRNA in neuroendocrine corticotropin-releasing hormone (CRH) neurons of the hypothalamic paraventricular nucleus (PVN) of male rats was examined 8 h following an acute immune challenge by intraperitoneal lipopolysaccharide (LPS, 250 microg/kg). Both quantitative, macroautoradiographic, single-label radioactive in situ hybridization histochemistry (ISHH) and qualitative dual-label ISHH were performed. Compared to controls, LPS-injected rats displayed increased (185%) parvicellular CCK mRNA expression levels, occurring in a majority (70%) of CRH neurons as revealed by dual-label ISHH.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleo Hipotalámico Paraventricular
/
Sistema Hipófiso-Suprarrenal
/
Colecistoquinina
/
Hormona Liberadora de Corticotropina
/
Sistema Hipotálamo-Hipofisario
/
Neuronas
Tipo de estudio:
Qualitative_research
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia