Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens.
Immunity
; 14(5): 617-29, 2001 May.
Article
en En
| MEDLINE
| ID: mdl-11371363
ABSTRACT
The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bazo
/
Streptococcus pneumoniae
/
Linfocitos B
/
Linfocitos T
/
Receptores de Complemento 3d
/
Antígenos Bacterianos
Límite:
Animals
Idioma:
En
Revista:
Immunity
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos