Your browser doesn't support javascript.
loading
Antifungal resistance of candidal biofilms formed on denture acrylic in vitro.
Chandra, J; Mukherjee, P K; Leidich, S D; Faddoul, F F; Hoyer, L L; Douglas, L J; Ghannoum, M A.
Afiliación
  • Chandra J; Center for Medical Mycology, University Hospitals of Cleveland and Case Western Reserve University, OH 44106-5028, USA.
J Dent Res ; 80(3): 903-8, 2001 Mar.
Article en En | MEDLINE | ID: mdl-11379893
Denture biofilms represent a protective reservoir for oral microbes. The study of the biology of Candida in these biofilms requires a reliable model. A reproducible model of C. albicans denture biofilm was developed and used to determine the susceptibility of two clinically relevant C. albicans isolates against 4 antifungals. C. albicans, growing as a biofilm, exhibited resistance to amphotericin B, nystatin, chlorhexidine, and fluconazole, with 50% reduction in metabolic activity (50% RMA) at concentrations of 8, 16, 128, and > 64 microg/mL, respectively. In contrast, planktonically cultured C. albicans were susceptible (50% RMA for the same antifungals was obtained at 0.25, 1.0, 4.0, and 0.5 microg/mL, respectively). In conclusion, results obtained by means of our biofilm model show that biofilm-associated C. albicans cells, compared with cells grown in planktonic form, are resistant to antifungals used to treat denture stomatitis.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas Acrílicas / Candida albicans / Biopelículas / Bases para Dentadura / Antifúngicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Dent Res Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas Acrílicas / Candida albicans / Biopelículas / Bases para Dentadura / Antifúngicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Dent Res Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos