Stereoselective total synthesis of chrysanthemol.
J Asian Nat Prod Res
; 3(2): 103-16, 2001.
Article
en En
| MEDLINE
| ID: mdl-11407809
ABSTRACT
Chrysanthemol (1), a trans-eudesmane type sesquiterpene from Chrysanthemum indicum L., possesses certain anti-inflammatory activity. Its total synthesis was approached from two alternative routes and finally accomplished in ten steps from R-(+)-carvone via alpha-eudesmol (10) as the key intermediate. The overall yield is 2.4% and the spectral data of the synthetic target compound were identical with that of natural chrysanthemol (1). Seven intermediary compounds were tested for inhibitory effects on the carragenan-induced swelling of mouse paw but demonstrated no obvious activities.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Chrysanthemum cinerariifolium
/
Terpenos
/
Medicamentos Herbarios Chinos
/
Antiinflamatorios no Esteroideos
/
Sesquiterpenos de Eudesmano
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2001
Tipo del documento:
Article