Uterine leiomyomas and their effect on in vitro fertilization outcome: a retrospective study.
J Assist Reprod Genet
; 18(3): 139-43, 2001 Mar.
Article
en En
| MEDLINE
| ID: mdl-11411428
ABSTRACT
PURPOSE:
The effect of uterine leiomyomas on the outcome of in vitro fertilization (IVF) treatment has been controversial. This study was undertaken to clarify influence of fibroids on IVF success, in a large population with age and other potential confounding variables controlled for in the analysis.METHODS:
A population of 141 patients with and 406 without leiomyomata undergoing their first IVF cycle was studied.RESULTS:
The association between uterine leiomyomas and assisted reproduction treatment outcome was not statistically significant (OR = 0.73, 95% CI 0.49-1.19, p = 0.21) after controlling for age and other risk factors. Also, fibroids neither affected the risk of spontaneous abortion (OR = 1.06, 95% CI 0.44-2.60) nor the risk of ectopic pregnancy (OR = 0.78, 95% CI 0.08-8.02). Location of fibroids (intramural vs. submucosal/subserosal) and their size had no significant effect on pregnancy outcome.CONCLUSIONS:
Results from our analyses indicated that in vitro fertilization outcome was not affected by the presence of uterine leiomyomas. Therefore, in patients with normal uterine cavities and fibroids less than a certain size (i.e., < 7 cm), undergoing myomectomies as a prerequisite for assisted reproduction treatment is seriously questionable.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Neoplásicas del Embarazo
/
Neoplasias Uterinas
/
Resultado del Embarazo
/
Fertilización In Vitro
/
Leiomioma
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
J Assist Reprod Genet
Asunto de la revista:
GENETICA
/
MEDICINA REPRODUTIVA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos