Expression of neuronal isoform of nitric oxide synthase in spinal neurons of neonatal rats after sciatic nerve transection.
Neurosci Lett
; 307(2): 61-4, 2001 Jul 13.
Article
en En
| MEDLINE
| ID: mdl-11427300
ABSTRACT
Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and examined nNOS expression by immunostaining in neurons of the sciatic pool and of other spinal levels on the 5th day after surgery. No correspondence was observed between the surviving motoneurons and nNOS positive cells. The appearance and distribution of nNOS positive neurons at all spinal levels and laminae were similar to those of adult animals. These results are at variance with previous studies which showed correlation between motoneuron loss after axotomy and number of NADPH-diaphorase positive motoneurons after sciatic transection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Degeneración Retrógrada
/
Médula Espinal
/
Óxido Nítrico Sintasa
/
Animales Recién Nacidos
/
Neuronas Motoras
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Brasil