The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx.
Dev Genes Evol
; 211(2): 103-7, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11455421
ABSTRACT
The HB9 homeobox gene has been cloned from several vertebrates and is implicated in motor neuron differentiation. In the chick, a related gene, MNR2, acts upstream of HB9 in this process. Here we report an amphioxus homologue of these genes and show that it diverged before the gene duplication yielding HB9 and MNR2. AmphiMnx RNA is detected in two irregular punctate stripes along the developing neural tube, comparable to the distribution of 'dorsal compartment' motor neurons, and also in dorsal endoderm and posterior mesoderm. We propose a new homeobox class, Mnx, to include AmphiMnx, HB9, MNR2 and their Drosophila and echinoderm orthologues; we suggest that vertebrate HB9 is renamed Mnx1 and MNR2 be renamed Mnx2.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Genes Homeobox
/
Cordados no Vertebrados
/
Proteínas de Homeodominio
/
Proteínas de Drosophila
Límite:
Animals
Idioma:
En
Revista:
Dev Genes Evol
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Reino Unido