Human parvovirus B19 infection in HIV-positive patients.
Rev Soc Bras Med Trop
; 34(3): 239-42, 2001.
Article
en En
| MEDLINE
| ID: mdl-11460208
ABSTRACT
Parvovirus B19 infects predominantly erythroid cells, leading to transient inhibition of erythropoiesis. Immunocompromised patients may be unable to produce neutralizing antibodies and may develop severe chronic anemia. Epidemiological studies done on Niterói population showed that B19 infection occurs periodically in late spring and summer. We report a study from 55 HIV infected patients attending an infectious diseases outpatient clinic in this city during a 5-month period in which B19 circulation was well documented. All patients were under anti-retroviral therapy. No anti-B19 IgM was found, but a high prevalence of IgG anti-B19 (91%) was observed. In six patients, B19 DNA was found by dot-blot hybridization techniques, but this was not confirmed by PCR. None of these 6 patients manifested anemia and only one had CD4 cell count below 200 x 10(7)/L. We conclude that persistent infection causing anemia is an infrequent finding in our HIV positive patients under drug therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Seropositividad para VIH
/
Parvovirus B19 Humano
/
Infecciones por Parvoviridae
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Año:
2001
Tipo del documento:
Article