Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway.
Med Pediatr Oncol
; 36(1): 115-7, 2001 Jan.
Article
en En
| MEDLINE
| ID: mdl-11464861
ABSTRACT
BACKGROUND AND PROCEDURE The CD95/CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferongamma (INFgamma)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line. RESULTS:
Modulation of CD95/CD95L expression and triggering of an autocrine apoptotic mechanism by IFNgamma suggest a potential role for INFgamma as a therapeutic agent for NB.CONCLUSIONS:
The evidence that retinoids induce apoptosis via tissue transglutaminase (tTG) and that N-methyl-D-aspartate (NMDA) and gp120 act through the nitric oxide synthase (NOS) activation pathway, indicates the existence of different molecular mechanisms of action, whose pharmacological exploitation might be used in an additive fashion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Regulación Neoplásica de la Expresión Génica
/
Interferón gamma
/
Apoptosis
/
Receptor fas
/
Proteínas de Neoplasias
/
Neuroblastoma
Límite:
Humans
Idioma:
En
Revista:
Med Pediatr Oncol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia