Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero.
Neurology
; 57(2): 255-60, 2001 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-11468309
ABSTRACT
OBJECTIVE:
To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS.METHODS:
Methamphetamine-exposed children (n = 12) and age-matched unexposed control subjects (n = 14) were evaluated with MRI, localized 1H-MRS, and a Child Behavior Checklist. Metabolite concentrations of N-acetyl-containing compounds (NA), total creatine (Cr), choline-containing compounds, myoinositol, and glutamate + glutamine were measured in the frontal white matter and striatum.RESULTS:
Despite an absence of visible structural abnormalities in either group, children exposed to methamphetamine in utero had higher [Cr] (+10%, p = 0.02) in the striatum. [NA], primarily a measure of N-acetylaspartate, was normal in both regions, which suggests no significant neuronal loss or damage in the two brain regions examined. There were no differences in reported behavior problems among the methamphetamine-exposed children relative to the unexposed group.CONCLUSIONS:
The authors found increased [Cr] in the striatum with relatively normal [NA] in children exposed to methamphetamine. These findings suggest an abnormality in energy metabolism in the brains of children exposed to methamphetamine in utero.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Encéfalo
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Espectroscopía de Resonancia Magnética
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Metanfetamina
Límite:
Child
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Neurology
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
EEUU
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ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA