Alcohol and aldehyde dehydrogenase activity in the stomach and small intestine of rats poisoned with methanol.
Hum Exp Toxicol
; 20(5): 255-8, 2001 May.
Article
en En
| MEDLINE
| ID: mdl-11476158
ABSTRACT
The activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were measured with fluorogenic naphthaldehydes in the stomach and small intestine homogenates of rats dosed with 6 g methanol/kg bw after 6, 12, 24 h and 2, 5, 7 days. After intoxication with a sublethal dose, the ADH activity measured with these naphthaldehydes and ALDH activities in the stomach and small intestine were significantly decreased. This inhibition is stronger in the stomach and probably depends on cell damage and protein denaturation. We conclude that the activity measured with 6-methoxy-2-naphthaldehyde (MONAL-62) may be due to the activity of rat ADH-1 isoenzyme, and the activity detected with 4-methoxy-1-naphthaldehyde (MONAL-41) to the activity of rat ADH-2 isoenzyme.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Solventes
/
Alcohol Deshidrogenasa
/
Metanol
/
Aldehído Deshidrogenasa
Límite:
Animals
Idioma:
En
Revista:
Hum Exp Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Polonia