Vitamin B-6-supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation.
J Nutr
; 131(8): 2204-7, 2001 Aug.
Article
en En
| MEDLINE
| ID: mdl-11481418
ABSTRACT
Male ICR mice were examined for the effect of vitamin B-6 [pyridoxine (PN) HCl] on azoxymethane-induced colon tumorigenesis. Mice were fed the diets containing 1, 7, 14 or 35 mg PN HCl/kg for 22 wk, and given a weekly injection of azoxymethane (5 mg/kg body) for the initial 10 wk. Compared with the 1 mg PN HCl/kg diet, 7, 14 and 35 mg PN HCl/kg diets significantly suppressed the incidence and number of colon tumors, colon cell proliferation and expressions of c-myc and c-fos proteins. For some variables, 14 and 35 mg PN HCl/kg diets were more effective than the 7 mg/kg diet. Supplemental vitamin B-6 had no influence on the number of colon apoptotic cells. The results suggest that elevating dietary vitamin B-6 suppresses colon tumorigenesis by reducing cell proliferation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridoxina
/
Azoximetano
/
Carcinógenos
/
Neoplasias del Colon
Límite:
Animals
Idioma:
En
Revista:
J Nutr
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón