The parkin gene is not a major susceptibility locus for typical late-onset Parkinson's disease.
Neurol Sci
; 22(1): 73-4, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11487208
ABSTRACT
We investigated the parkin gene in 118 patients with typical Parkinson's disease (PD), i.e. in patients who had an onset of PD after the age of 45 years. The study group included 95 subjects with sporadic PD and 23 subjects from 18 families with autosomal recessive PD. No pathogenetic mutations in the parkin gene were detected either in familial or in sporadic patients. Our findings indicate that the parkin gene is not involved in the pathogenesis of classic late-onset PD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mutación Puntual
/
Predisposición Genética a la Enfermedad
/
Trastornos Parkinsonianos
/
Ubiquitina-Proteína Ligasas
/
Ligasas
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurol Sci
Asunto de la revista:
NEUROLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia