[Circadian rhythms of hemodynamic load on the cardiovascular system in patients with essential hypertension: implication for drug therapy rationale]. / Tsirkadiannyi ritm gemodinamicheskoi nagruzki na serdechno-sosudistuiu sistemu u bol'nykh éssentsial'noi arterial'noi gipertenziei -- znachenie dlia ratsional'noi farmakoterapii.

Circadian rhythm of hemodynamic load by double product (heart rate x systolic blood pressure) was studied in 224 patients with essential hypertension (EH) treated with different antihypertensive drugs for 8-12 weeks and in 23 healthy subjects. The main feature of the rhythm was a marked morning rise in all the patients including non-dippers and night-peakers without nocturnal blood pressure fall. The examined drugs showed different effects on mean 24-h and morning values of the double product.