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[Clinical value of native and contrast enhanced MRI in staging prostatic carcinoma before planned radical prostatectomy]. / Klinischer Stellenwert der nativen und KM-unterstützten MRT im Staging des Prostatakarzinoms vor geplanter radikaler Prostatektomie.
Kuhn, M; Huttmann, P; Spielhaupter, E; Gross-Fengels, W; Schreiter, F.
Afiliación
  • Kuhn M; Abt. für Diagnostische Radiologie, Allgemeines Krankenhaus, Hamburg.
Rofo ; 173(7): 595-600, 2001 Jul.
Article en De | MEDLINE | ID: mdl-11512230
PURPOSE: To assess the clinical value of MRI with and without contrast agent in the staging of prostatic carcinoma. Relevance for surgical management. METHODS: 60 patients with carcinoma proven by biopsy or suspected prostatic carcinoma were evaluated with MRI. The examinations were performed in a 1.5 T (Philips ACS-NT Gyroscan) imager with multiplanar orientations before and after intravenous application of 0.1 mmol/kg/bw Gadodiamide (Omniscan-Nycomed/Amersham). The gold standard was histology after radical prostatectomy and in case of non-operability the consensual final staging. RESULTS: Compared to histology MRI revealed a sensitivity of 75% and a specificity of 82% in the differentiation of locally advanced carcinoma (T 3/4). Including the non-surgical cases MRI showed a sensitivity of 82.5% and a specificity of 86%. Interindividual analysis showed no difference in diagnostic accuracy between the non-enhanced and the contrast-enhanced techniques. In 23% of cases (n = 14) MRI induced changes in patient management. CONCLUSIONS: MRI is an accurate procedure in the local staging of prostatic carcinoma. In combination with clinical findings, PSA, and grading scores MRI has a significant influence on treatment selection. Contrast agent administration does not seem to increase the diagnostic accuracy significantly.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prostatectomía / Neoplasias de la Próstata / Imagen por Resonancia Magnética / Aumento de la Imagen / Medios de Contraste / Gadolinio DTPA Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: De Revista: Rofo Año: 2001 Tipo del documento: Article Pais de publicación: Alemania
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prostatectomía / Neoplasias de la Próstata / Imagen por Resonancia Magnética / Aumento de la Imagen / Medios de Contraste / Gadolinio DTPA Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: De Revista: Rofo Año: 2001 Tipo del documento: Article Pais de publicación: Alemania