The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation.
Eur J Pharm Biopharm
; 52(2): 197-202, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11522486
ABSTRACT
Experimental factorial design was used to evaluate the influence of two factors involved in producing cholesteryl butyrate (chol-but) solid lipid nanospheres (SLN), microemulsion formulation and microemulsion/water ratio, on the effect of the SLN on the proliferation of NIH-H460, a non-small-cell lung carcinoma; six experimental settings were tested. The cells were treated with scalar concentrations of cholesteryl butyrate (from 0.008 to 1.000 mM) for each experimental condition; NIH-H460 cell growth was inhibited in all cases. The best experimental setting provided complete inhibition at 0.125 mM chol-but, while at the same concentration sodium butyrate provided only 38% inhibition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ésteres del Colesterol
/
Ácido Butírico
/
Antagonistas de los Receptores Histamínicos
Límite:
Humans
Idioma:
En
Revista:
Eur J Pharm Biopharm
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia