Effect of Alpinia oxyphylla fruit extract on compound 48/80-induced anaphylactic reactions.
Am J Chin Med
; 29(2): 293-302, 2001.
Article
en En
| MEDLINE
| ID: mdl-11527071
ABSTRACT
The effect of the aqueous extract of Alpinia oxyphylla Miq. (Zingiberaceae) fruits (AOFE) on anaphylactic reaction was investigated. AOFE completely inhibited compound 48/80-induced systemic anaphylactic shock at dose of 1.0 g/kg. When AOFE was pretreated at concentrations ranging from 0.01 to 1.0 g/kg, the plasma histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. AOFE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when AOFE was added, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that AOFE may be beneficial in the treatment of non-specific anaphylactic reactions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
AMP Cíclico
/
Antagonistas de los Receptores Histamínicos H1
/
Liberación de Histamina
/
Anafilaxia
/
Mastocitos
Límite:
Animals
Idioma:
En
Revista:
Am J Chin Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Corea del Sur