Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
J Med Chem
; 44(19): 3195-8, 2001 Sep 13.
Article
en En
| MEDLINE
| ID: mdl-11543689
ABSTRACT
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inhibidores de la Colinesterasa
/
Cumarinas
/
Inhibidores de la Monoaminooxidasa
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suiza