The role of the activin-follistatin system in the developmental and regeneration processes of the kidney.
Cytokine Growth Factor Rev
; 12(4): 289-98, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11544099
ABSTRACT
Regeneration processes in many tissues are modulated by various factors, which are involved in their organogenesis. Activin A, a member of the TGF-beta superfamily, inhibits branching tubulogenesis of the kidney in organ culture system as well as in in vitro tubulogenesis model. On the other hand, follistatin, an antagonist activin A, reverses the effect of activin A on kidney development, induces branching tubulogenesis, and also promotes tubular regeneration after ischemia/reperfusion injury by blocking the action of endogenous activin A. The activin-follistatin system is one of the important regulatory systems modulating developmental and regeneration processes of the kidneys.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Activinas
/
Riñón
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón