Monocyte integrin expression and monocyte-platelet complex formation in humans with coronary restenosis.
Clin Exp Pharmacol Physiol
; 28(10): 804-8, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11553019
1. In the present study, we sought to determine whether patients with restenosis after coronary stenting possess increased monocyte reactivity, as manifested by a higher level of adhesion molecule expression and an enhanced propensity to form monocyte-platelet aggregates after activation in vitro. 2. Anti-coagulated peripheral venous blood from 24 patients, 10 with and 14 without angiographically verified restenosis, was obtained. Leucocyte antigen expression and the number of leucocyte-platelet complexes were measured by flow cytometry after activation in whole blood. 3. Surface integrin Mac-1 (CD11b/CD18) and VLA-4 (CD49d/ CD29) expression on monocytes and the relative number of monocyte-platelet complexes after in vitro activation were significantly elevated in patients with restenosis compared with patients without restenosis (fluorescence intensities of 1425 +/- 76 vs 1195 +/- 71, 87 +/- 7 vs 65 +/- 6 and 47 +/- 4 vs 29 +/- 3% for for Mac-1, VLA-4 and monocyte-platelet complexes, respectively; P < 0.05 for each parameter). 4. The results suggest that restenosis is associated with increased monocyte VLA-4 and Mac-1 integrin expression and monocyte-platelet complex formation, which can be revealed after activation in vitro.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Monocitos
/
Integrinas
/
Reestenosis Coronaria
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Australia