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Effect of the inflammation, chronic hyperglycemia, or malabsorption on the apolipoprotein A-IV concentration in type 1 diabetes mellitus and in diabetes secondary to chronic pancreatitis.
Quilliot, D; Walters, E; Guerci, B; Fruchart, J C; Duriez, P; Drouin, P; Ziegler, O.
Afiliación
  • Quilliot D; Service de Diabétologie, Maladies Métaboliques et Nutrition, Hôpital Jeanne d'Arc, CHU de Nancy, Toul, France. d.quilliot@chu-nancy.fr
Metabolism ; 50(9): 1019-24, 2001 Sep.
Article en En | MEDLINE | ID: mdl-11555832
ABSTRACT
The metabolism of apolipoprotein (apo) A-IV in diabetes mellitus (DM) is poorly understood. Several factors, such as dietary fat intake, fat malabsorption, acute inflammation, and hormonal dysregulation can disturb the plasma apo A-IV concentration. We have compared the plasma apo A-IV concentrations in patients with type 1 DM and DM secondary to chronic pancreatitis to determine the effects of combinations of these factors. We examined 4 groups of male patients with chronic pancreatitis without diabetes (ND-CP) (n = 12), diabetes secondary to chronic pancreatitis and insulin-treated (CP-DM) (n = 32), type 1 diabetes (n = 25), and controls (n = 20). Plasma apo A-IV was significantly lower in the chronic pancreatitis patients (ND-CP and CP-DM) than in the other patients. Inflammatory proteins (fibrinogen, ceruloplasmin, and haptoglobin) were significantly elevated in the 2 chronic pancreatitis groups. The apo A-IV concentration was positively correlated with hemoglobin A(1c) (HbA(1c)) percentage in each group of diabetic patients (CP-DM, r =.35; P =.046; type 1 DM, r =.53; P =.010), in both groups of diabetic patients (r =.472; P <.0001) and negatively correlated with ceruloplasmin concentration in each group of diabetic patients (CP-DM, r = -.48; P =.0052; type 1 DM, r = -.66; P =.003), in both groups of diabetic patients (r = -.561; P <.0001), and in the whole population (r = -.463; P <.0001). Apo A-IV was also negatively correlated with haptoglobin in type 1 DM patients (r = -.434; P =.0435), in the both groups of diabetic patients (r = -.349; P =.0154), and in the whole population (r = -.351; P =.0019). Multiple linear regression analysis revealed that only HbA(1c) and ceruloplasmin were independent explanatory variables. Plasma apo A-IV is positively correlated with HbA(1c) suggesting that hyperglycemia per se selectively affects apo A-IV metabolism. The correlation between the concentrations of inflammatory protein and apo A-IV suggest a link between chronic inflammation and apo A-IV synthesis or catabolism. As apo A-IV is involved in reverse cholesterol transport, its low level in CP-DM may contribute to the accelerated development of atherosclerosis in these patients.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Apolipoproteínas A / Diabetes Mellitus Tipo 1 / Hiperglucemia / Síndromes de Malabsorción Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Metabolism Año: 2001 Tipo del documento: Article País de afiliación: Francia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Apolipoproteínas A / Diabetes Mellitus Tipo 1 / Hiperglucemia / Síndromes de Malabsorción Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Metabolism Año: 2001 Tipo del documento: Article País de afiliación: Francia