Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor.
Cancer Res
; 61(18): 6656-9, 2001 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-11559529
ABSTRACT
The molecular basis of carcinogenesis in gastrointestinal carcinoid tumors is not well understood. To clarify the contribution of the Wnt/beta-catenin signaling to this type of carcinogenesis, we investigated 72 cases of gastrointestinal carcinoid tumor both immunohistochemically and by direct sequencing of beta-catenin. Accumulation of beta-catenin in the cytoplasm and/or nucleus was observed in 57 cases (79.2%). We also detected mutations in exon 3 of beta-catenin in 27 cases (37.5%) and one mutation in APC (1.4%). Our results suggest that alterations in the Wnt/beta-catenin signaling pathway may be involved in the development of gastrointestinal carcinoid tumors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tumor Carcinoide
/
Transactivadores
/
Proteínas del Citoesqueleto
/
Proteínas de Pez Cebra
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Neoplasias Gastrointestinales
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Mutación
Límite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Res
Año:
2001
Tipo del documento:
Article