Event-related potentials in schizophrenia during tonal and phonetic oddball tasks: relations to diagnostic subtype, symptom features and verbal memory.
Biol Psychiatry
; 50(6): 447-52, 2001 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-11566162
ABSTRACT
BACKGROUND:
This study compares event-related potentials for paranoid patients (n = 13) versus matched undifferentiated patients and unmedicated patients (n = 14) versus matched healthy adults.METHODS:
Event-related potentials of right-handed patients and control subjects were recorded from 30 electrodes during oddball tasks using consonant-vowel syllables or complex tones. Patients were also assessed using the Positive and Negative Syndrome Scale, the Thought Disorder Index, and the Wechsler Memory Scale.RESULTS:
Paranoid patients did not differ from undifferentiated patients in N1 or P3 amplitude but showed larger N2 at frontocentral sites to phonetic stimuli, as well as larger N2 over left than right hemisphere. Unmedicated patients showed reduced N2, but not N1 or P3, compared to control subjects.CONCLUSIONS:
The N2 findings are consistent with neuropsychological evidence of greater verbal abilities and left hemisphere dominance in paranoid than nonparanoid schizophrenia. The findings also confirm the relationship of P3 to total Brief Psychiatric Rating Scale score, negative symptoms, and verbal associative memory.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia Paranoide
/
Vocabulario
/
Potenciales Evocados Auditivos
/
Trastornos de la Memoria
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Biol Psychiatry
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos