Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndrome.
Am J Gastroenterol
; 96(9): 2671-6, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11569693
ABSTRACT
OBJECTIVE:
To evaluate the influence of gender on the effect of a 5-HT3 antagonist, alosetron, 1 mg b.i.d., on GI and colonic transit in D-IBS.METHODS:
Thirty patients (15 male, 15 female) with D-IBS received 1 mg b.i.d. alosetron for 6 wk. Transit was measured by scintigraphy at baseline and at the end of treatment.RESULTS:
Alosetron, 1 mg b.i.d., significantly retarded small bowel and, proximal and overall colonic transit in the 30 patients with D-IBS. The effect of alosetron on the primary endpoint, colonic geometric center at 24 h, was significantly greater in females than in males (p < 0.05). However, two females showed no slowing of colonic transit on treatment. Among male patients, two of 15 had a slowing of colonic transit at 24 h that was greater than the mean change in female patients, suggesting responsiveness to alosetron among a subgroup of males.CONCLUSION:
A 5-HT3 antagonist, alosetron, significantly retards small intestinal and colonic transit in diarrhea-predominant IBS patients, with significantly greater female to male responsiveness. Gender partly contributes to differences in the serotonergic control of intestinal and colonic transit in patients with D-IBS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antagonistas de la Serotonina
/
Carbolinas
/
Tránsito Gastrointestinal
/
Colon
/
Enfermedades Funcionales del Colon
/
Diarrea
Aspecto:
Determinantes_sociais_saude
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Gastroenterol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos