Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate.
Biomaterials
; 22(22): 3073-81, 2001 Nov.
Article
en En
| MEDLINE
| ID: mdl-11575483
ABSTRACT
Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polímeros
/
Materiales Biocompatibles
/
Ácido Láctico
/
Holmio
Límite:
Humans
Idioma:
En
Revista:
Biomaterials
Año:
2001
Tipo del documento:
Article
País de afiliación:
Países Bajos