Uniform platelet activation exists before coronary stent implantation despite aspirin therapy.
Am Heart J
; 142(4): 611-6, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11579350
ABSTRACT
BACKGROUND:
Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated.METHODS:
Platelets were assessed before intervention by platelet-rich plasma aggregation (PA) with 5 mmol adenosine diphosphate (ADP) and 1 mg/mL collagen; whole blood aggregation (WBA) by 1 mg/mL collagen; shear-induced closure time (CT); contractile force (CF); and expression of 9 surface receptors by flow cytometry in 126 patients undergoing elective coronary artery stent placement. All patients received aspirin for at least 7 days. The data were compared with those from 64 healthy volunteers.RESULTS:
Each test revealed sustained platelet activation in patients undergoing coronary stenting compared with control values. These differences were significant for collagen-induced PA (P =.031); CF (P =.0001); expression of glycoprotein (GP) IIb/IIIa (P =.0001); P-selectin (P =.0008); platelet/endothelial cell adhesion molecule (PECAM)-1 (P =.0001); CD107a (P =.0001); CD107b (P =.0004); and CD63 (P =.009).CONCLUSION:
Platelets are indeed activated before coronary stenting despite antecedent therapy with aspirin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cuidados Preoperatorios
/
Inhibidores de Agregación Plaquetaria
/
Activación Plaquetaria
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Stents
/
Aspirina
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Enfermedad Coronaria
Límite:
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am Heart J
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA